Melanotan II
In stockMelanotan 2Lactam-bridged cyclic heptapeptide, an analogue of alpha-MSH(4-10) and a potent, non-selective agonist at human melanocortin receptors. Researchers study melanocortin receptor pharmacology and signalling.
Supplied as a single-chamber lyophilized vial with a colour-coded cap (Hormone & Libido).
Research literature, not dosing or treatment instructions.
- A 2022 medicinal-chemistry paper replaced the lactam cyclisation of melanotan II with scaffold chemistry and profiled functional selectivity at human melanocortin receptors. (PMID 35188390)
- A review covers the physiology of the melanocortin system: receptors, POMC-derived agonists and endogenous antagonists. (PMID 17077189)
Add the solvent slowly along the vial wall; swirl gently, never shake. Allow to dissolve fully. Six-step guide with photos →
Concentration calculator only. Enter the mass being calculated; blend components are not added automatically. Products are for in-vitro research.
Refer to the product label and supplier documentation for storage conditions. Lot-specific storage and expiry information is not available here.
Each certificate is published with its lot number.
Questions about Melanotan II
How much published research is there on Melanotan II?
The research library's PubMed search for Melanotan II returned 624 records on 5 October 2026, 32 of them reviews. The library lists 3 studies chosen for what they measured. ClinicalTrials.gov lists 1 registered studies naming Melanotan II, 1 of them sponsored by Hudson Biotech (checked 5 October 2026).
Is Melanotan II an approved medicine?
No medicinal product containing Melanotan II is listed in Drugs@FDA (checked 5 October 2026), and the research material we supply is not a medicine. It is supplied for in-vitro laboratory research only, not for human or veterinary use.
Is Melanotan II the same as Melanotan 2?
Yes. The literature writes the name as melanotan II, melanotan-II, MT-II and melanotan 2 for the same lactam-bridged cyclic heptapeptide.
How does Melanotan II differ from PT-141?
PT-141 and melanotan II are cyclic heptapeptide melanocortin receptor agonists with the same lactam-bridged core. They differ at the C-terminus: PT-141 ends in a free acid and melanotan II in an amide.
How is the identity of Melanotan II confirmed on a certificate?
A research-grade certificate of analysis typically reports identity by mass spectrometry and purity by HPLC. The mass result is read against the average molecular weight of 1024.2 Da listed on this page. The research library's guide to reading a certificate explains each field.
What other names is Melanotan II published under?
Melanotan II is also written Melanotan 2 and MT-II. The catalog lists it under the name Melanotan II.
Is this product for human use?
No. Peptency products are supplied for in-vitro research only. Not for human or veterinary use, not for diagnosis or therapy.
Where can I find shipping information?
Current shipping rates and delivery information are on the Shipping & payment page, and the rates that apply to your order are shown at checkout.
Often studied with
For research use only. Not for human or veterinary use.
What is Melanotan II?
Melanotan II is the lactam-bridged cyclic heptapeptide Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, an analogue of alpha-MSH(4-10) that is a potent, non-selective agonist at human melanocortin receptors. It has no marketing authorisation recorded in the databases checked. We supply Melanotan II as a lyophilized vial for in-vitro laboratory research only.
What are the chemical identifiers of Melanotan II?
Melanotan II has the molecular formula C50H69N15O9, an average molecular weight of 1024.2 Da and CAS number 121062-08-6.
Chemistry checked against PubChem (CID 92432), 5 October 2026; full chemistry record in the research library.
What does published research on Melanotan II cover?
A PubMed search for Melanotan II returned 624 records on 5 October 2026, 32 of them reviews. Our research library lists 3 of these studies, chosen for what they measured.
- A 2022 medicinal-chemistry paper replaced the lactam cyclisation of melanotan II with scaffold chemistry and profiled functional selectivity at human melanocortin receptors. (Tomassi et al., J Med Chem, 2022; PMID 35188390)
- A review covers the physiology of the melanocortin system: receptors, POMC-derived agonists and endogenous antagonists. (Cone, Endocr Rev, 2006; PMID 17077189)
Mechanism, every cited study and the regulator records are on the Melanotan II page of the research library. Papers are listed by what they measured, not as evidence of any use.
How is Melanotan II supplied and stored?
Melanotan II is supplied as a lyophilized (freeze-dried) powder in a sealed vial, for in-vitro laboratory research only. Our stated storage condition for the sealed lyophilized vial is 2 to 8 °C. The label and the lot certificate carry the lot-specific storage condition and expiry date.
What is the regulatory status of Melanotan II?
Drugs@FDA lists no application naming melanotan as an active ingredient (checked 5 October 2026).
A regulator record is information about a database entry. It is not advice and not a statement that any use is lawful or unlawful in any country. How regulators approach research peptides.
Which related research pages and compounds are listed?
- Melanotan II: chemistry, literature and regulatory status
- Melanotan II compared with PT-141
- Melanocortin receptors
- How to read a certificate of analysis
Related compounds in the catalog: