MOTS-c
In stockMitochondrial ORF of the 12S rRNA-c16-residue peptide encoded by a short open reading frame in the mitochondrial 12S rRNA gene. Researchers study it as a mitochondria-derived signalling peptide that can move to the nucleus under metabolic stress.
Supplied as a single-chamber lyophilized vial with a colour-coded cap (Longevity & Energy).
Research literature, not dosing or treatment instructions.
- The discovery paper identified the open reading frame in mitochondrial DNA and reported metabolic effects in cells and mice. (PMID 25738459)
- MOTS-c was shown to translocate to the nucleus in response to metabolic stress and to regulate nuclear gene expression. (PMID 29983246)
- A 2026 paper identifies MOTS-c as a mitochondria-encoded host defense peptide with interferon-linked activity. (PMID 42611943)
Add the solvent slowly along the vial wall; swirl gently, never shake. Allow to dissolve fully. Six-step guide with photos →
Concentration calculator only. Enter the mass being calculated; blend components are not added automatically. Products are for in-vitro research.
Refer to the product label and supplier documentation for storage conditions. Lot-specific storage and expiry information is not available here.
Each certificate is published with its lot number.
Questions about MOTS-c
How much published research is there on MOTS-c?
The research library's PubMed search for MOTS-c returned 262 records on 5 October 2026, 57 of them reviews. The library lists 4 studies chosen for what they measured. ClinicalTrials.gov lists 5 registered studies naming MOTS-c (checked 5 October 2026).
Is MOTS-c an approved medicine?
No medicinal product containing MOTS-c is listed in Drugs@FDA (checked 5 October 2026), and the research material we supply is not a medicine. It is supplied for in-vitro laboratory research only, not for human or veterinary use.
Where is MOTS-c encoded?
In a short open reading frame of the mitochondrial 12S rRNA gene, which the discovery paper identified in mitochondrial DNA (PMID 25738459). A later study reported that MOTS-c translocates to the nucleus in response to metabolic stress (PMID 29983246).
How is the identity of MOTS-c confirmed on a certificate?
A research-grade certificate of analysis typically reports identity by mass spectrometry and purity by HPLC. The mass result is read against the average molecular weight of 2174.6 Da listed on this page. The research library's guide to reading a certificate explains each field.
What other names is MOTS-c published under?
MOTS-c is also written Mitochondrial ORF of the 12S rRNA-c and MOTS c. The catalog lists it under the name MOTS-c.
Is this product for human use?
No. Peptency products are supplied for in-vitro research only. Not for human or veterinary use, not for diagnosis or therapy.
Where can I find shipping information?
Current shipping rates and delivery information are on the Shipping & payment page, and the rates that apply to your order are shown at checkout.
Often studied with
For research use only. Not for human or veterinary use.
What is MOTS-c?
MOTS-c is a 16-residue peptide encoded by a short open reading frame in the mitochondrial 12S rRNA gene. Research describes it as a mitochondrial-derived signalling peptide that can enter the nucleus under metabolic stress. We supply MOTS-c as a lyophilized vial for in-vitro laboratory research only.
What are the chemical identifiers of MOTS-c?
MOTS-c has the molecular formula C101H152N28O22S2, an average molecular weight of 2174.6 Da and CAS number 1627580-64-6.
Chemistry checked against PubChem (CID 146675088), 5 October 2026; full chemistry record in the research library.
What does published research on MOTS-c cover?
A PubMed search for MOTS-c returned 262 records on 5 October 2026, 57 of them reviews. Our research library lists 4 of these studies, chosen for what they measured.
- The discovery paper identified the open reading frame in mitochondrial DNA and reported metabolic effects in cells and mice. (Lee et al., Cell Metab, 2015; PMID 25738459)
- MOTS-c was shown to translocate to the nucleus in response to metabolic stress and to regulate nuclear gene expression. (Kim et al., Cell Metab, 2018; PMID 29983246)
- A 2026 paper identifies MOTS-c as a mitochondria-encoded host defense peptide with interferon-linked activity. (Rice et al., Elife, 2026; PMID 42611943)
Mechanism, every cited study and the regulator records are on the MOTS-c page of the research library. Papers are listed by what they measured, not as evidence of any use.
How is MOTS-c supplied and stored?
MOTS-c is supplied as a lyophilized (freeze-dried) powder in a sealed vial, for in-vitro laboratory research only. Our stated storage condition for the sealed lyophilized vial is 2 to 8 °C. The label and the lot certificate carry the lot-specific storage condition and expiry date.
What is the regulatory status of MOTS-c?
Drugs@FDA lists no application naming MOTS-c as an active ingredient (checked 5 October 2026).
The WADA 2026 Prohibited List names this substance under S4.4. A WADA entry is a sporting rule, not a statement about legality outside sport.
A regulator record is information about a database entry. It is not advice and not a statement that any use is lawful or unlawful in any country. How regulators approach research peptides.
Which related research pages and compounds are listed?
- MOTS-c: chemistry, literature and regulatory status
- Mitochondria-linked peptides
- How to read a certificate of analysis
Related compounds in the catalog: