FDA
No application listedNo application naming delta sleep-inducing peptide or DSIP as an active ingredient is listed in Drugs@FDA. Checked 2026-10-05; the control lookup (semaglutide) returned 6 applications.
Drugs@FDA via openFDADSIP: chemistry, literature and regulatory status
Research-use information. This page summarises published literature and regulator records. It is not guidance for use, not medical advice, and not a statement that any material is suitable for use in people or animals.
What is DSIP?
DSIP, delta sleep-inducing peptide, is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, isolated in 1977 from the cerebral venous blood of rabbits. Its mechanism remains incompletely characterised, and the foundational literature dates from the 1970s and 1980s. It is supplied here as a research material for laboratory use only.
What are the chemical facts for DSIP?
- Name
- DSIP
- Also written
- Delta sleep-inducing peptide
- Sequence
- Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Length
- 9 residues
- Molecular formula
C35H48N10O15(matches the formula computed from the sequence)- Average molecular weight
- 848.8 g/mol
- CAS number
62568-57-4(confirmed in PubChem)- PubChem
- CID 68816
Chemistry checked against PubChem on 2026-10-05. Where the formula can be computed from the listed sequence, it was, and the two routes agree.
How does the literature describe the mechanism of DSIP?
- The original paper isolated the peptide from rabbit cerebral venous blood, determined its sequence and tested the peptide and analogues for effects on EEG activity in rabbits.[4],[3]
- A 1986 review updates the literature on sleep and other effects in animals and humans.[2]
- Degradation and aggregation of DSIP and two analogues were measured in human and rat blood plasma and serum.[1]
What has published research on DSIP looked at?
4 studies are cited for DSIP. Each is labelled by design below, and each entry says what the paper measured.
- 1 in vitro
- 1 review
- 1 chemistry
- 1 animal study and chemistry
PubMed returns 462 records for the search terms published on the method page (24 of them with a review publication type, 18 with a clinical-trial publication type), checked 5 October 2026. ClinicalTrials.gov lists 0 registered studies whose intervention matches the name (0 interventional), checked 5 October 2026.
Studies are listed by what they measured. Papers whose titles state an amount or schedule, or describe a clinical outcome of an approved medicine, are not listed. This is a wording rule, not a quality filter; see the method page.
What is the regulatory status of DSIP?
EMA
No centrally authorised medicine listedNo centrally authorised procedure in the EMA medicines database (checked 5 October 2026) names DSIP as an active substance. National authorisations are not in this dataset.
EMA medicines dataMHRA
No product document foundNo SmPC, PIL or PAR document in MHRA Products matches the exact name "delta sleep-inducing peptide". Checked 2026-10-05; the control lookup (semaglutide) returned 271 documents.
MHRA ProductsWADA
Not namedThe WADA 2026 Prohibited List, in force 1 January 2026 does not name this substance. The list names substances by example, so this is not a statement that it is permitted in sport.
WADA Prohibited List 2026A regulator record is information about a database entry. It is not advice and not a statement that any use is lawful or unlawful in any country. How regulators approach research peptides.
Data dates: regulatory records 2026-10-05; WADA list 2026-10-05.
Which studies are cited for DSIP?
[1] Graf MV, Saegesser B, Schoenenberger GA. Degradation and aggregation of delta sleep-inducing peptide (DSIP) and two analogs in plasma and serum. Peptides. 1987;8:599-603.
Measured degradation and aggregation of DSIP and two analogues in human and rat blood plasma and serum.
[2] Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): an update. Peptides. 1986;7:1165-87.
Update review of the DSIP literature on sleep and other effects in animals and humans.
[3] Schoenenberger GA, Maier PF, Tobler HJ, Wilson K, Monnier M. The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. Pflugers Arch. 1978;376:119-29.
Amino-acid analysis, sequence and synthesis of the nonapeptide DSIP, with activity testing.
[4] Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74:1282-6.
Isolation of DSIP from rabbit cerebral venous blood, sequence determination and EEG tests of the peptide and analogues in rabbits.
Data dates: citations read from PubMed 2026-10-05.
Where else in the research library is DSIP covered?
Who wrote this page and how is it checked?
Peptency editorial team, last reviewed 5 October 2026. Citations are read back from PubMed, chemistry is checked against PubChem, and regulator records are read from each regulator's own database on the dates shown. The method page lists every source, search term and rule. Corrections are welcome through the contact details on the About page.